PhD position “4D cone beam computed tomography as a novel tool for accurate time-resolved dose calculation in particle therapy”

Position: PhD position “4D cone beam computed tomography as a novel tool for accurate time-resolved dose calculation in particle therapy”

Institution: Department of Medical Physics of the Faculty of Physics and Department of Radiation Oncology of the University Hospital of the Ludwig-Maximilians-Universität München

Location: Munich, Germany

Application closes at: May 1st, 2019 23:59

DFG funded project “4D cone beam computed tomography as a novel tool for accurate time-resolved dose calculation in particle therapy”
1 PhD position available

In a research project funded by the German Research Foundation (DFG) based jointly at the Department of Medical Physics of the Faculty of Physics, and the Department of Radiation Oncology of the University Hospital of the Ludwig-Maximilians-Universität München (LMU), a PhD position in Physics investigating 4D cone beam computed tomography (4DCBCT) for image guidance and dose calculation in particle therapy is available.

At the LMU we have developed several CBCT correction methods (http://dx.doi.org/10.1118/1.4908223) allowing proton (http://dx.doi.org/10.1118/1.4962933) and photon dose calculations (http://dx.doi.org/10.1016/j.radonc.2017.09.020). These methods have been extensively tested in 3D and proven successful; however the extension to 4D, accounting for breathing motion, remains a challenge.

The general goals of the project are threefold: (1) improve the quality of 4DCBCT images by imaging protocol optimization and image reconstruction improvements using iterative techniques. (2) On the basis of improved 4DCBCT images, extend the LMU correction methods to 4D. Finally (3) the impact on timeresolved proton therapy dose calculations for moving lung and liver tumors will be studied.

The research project will offer a broad spectrum of tasks including the use of iterative image reconstruction, deformable image registration, 4D Monte Carlo dose calculations and general handling of 4D data. Moreover, extensive imaging data acquisition using moving phantoms at the LMU’s Department of Radiation Oncology’s CT and CBCT scanners will be performed. The project duration will be 36 months.

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