PhD position “4D cone beam computed tomography as a novel tool for accurate timeresolved dose calculation in particle therapy”

Position: PhD position “4D cone beam computed tomography as a novel tool for accurate timeresolved dose calculation in particle therapy”

Institution: Department of Medical Physics of the Faculty of Physics and Department of Radiation Oncology of the University Hospital of the Ludwig-Maximilians-Universität München (LMU)

Location: Munich, Germany

Application closes at: Mar 15th, 2018 23:59

DFG funded project
“4D cone beam computed tomography as a novel tool for accurate time-resolved dose calculation in particle therapy”


1 PhD position available

In a research project funded by the German Research Foundation (DFG) based jointly at the De-partment of Medical Physics of the Faculty of Physics, and the Department of Radiation Oncolo-gy of the University Hospital of the Ludwig-Maximilians-Universität München (LMU), a PhD po-sition in Physics investigating 4D cone beam computed tomography (4DCBCT) for image guid-ance and dose calculation in particle therapy is available.
At the LMU we have developed several CBCT correction methods (http://dx.doi.org/10.1118/1.4908223) allowing proton (http://dx.doi.org/10.1118/1.4962933) and photon dose calculations (http://dx.doi.org/10.1016/j.radonc.2017.09.020). These methods have been extensively tested in 3D and proven successful; however the extension to 4D, ac-counting for breathing motion, remains a challenge.
The general goals of the project are threefold: (1) improve the quality of 4DCBCT images by im-aging protocol optimization and image reconstruction improvements using iterative techniques. (2) On the basis of improved 4DCBCT images, extend the LMU correction methods to 4D. Finally (3) the impact on time-resolved proton therapy dose calculations for moving lung and liver tu-mors will be studied.
The research project will offer a broad spectrum of tasks including the use of iterative image reconstruction, deformable image registration, 4D Monte Carlo dose calculations and general handling of 4D data. Moreover, extensive imaging data acquisition using moving phantoms at the LMU’s Department of Radiation Oncology’s CT and CBCT scanners will be performed. The salary will be 50% TV-L E13 for a duration of 36 months.
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